Current global trends and increasing consumer needs demand for superior cosmetic product efficacies. This requires a constant evolution of test designs for product evaluation. Dexpanthenol (DEX) is broadly used for decades as an active ingredient in various cosmetic applications and thereby known for several proven effects , like increase of skin hydration, support of moisture retain , and enhancement of epidermal barrier recovery . In contrast, data concerning DEX kinetic, and penetration are rare. Therefore, the present work focuses on the penetration of DEX.
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